By airplane: From Havana, it takes about 1 hours and 30 minutes and there are 6 flights per week.
By bus: From Havana, it takes about 8 hours and 30 minutes by bus and costs approximately $33 USD/CUC.
Víazul (www.viazul.com) has two daily buses from Havana to Camagüey and three buses to be back to Havana.
Make sure to book your bus ticket at least a day in advance, the buses frequently sell out a day in advance. You can book your tickets here, but prices are cheaper at the bus stations.
Renting a car is another option. Booking a car rental in Cuba is not easy, so make sure to book a car several weeks, if not months, in advance online.