Airplane：From Havana 1-2 flights per day, 1 hour and 40 minutes
Bus：From Havana, 11 hours. The price is approximately 39USD/CUC
By Víazul(http://www.viazul.com/), you may take the bus rute HAVANA/HOLGUIN, or also there is rute HAVANA/SANTIAGO DE CUBA which stops by Holguin.
To guarantee the trip you must make the reservation before the last day before the departure. Often, the last day before the trip all the tickets are sold. You can make the reservation from the site. Please confirm the price in the Bus Station.
Rent a Car is also an option. However, it is kind of complicated the procedure for making the reservation in Cuba. You should make the reservation online and some weeks before your trip.